Plant natural products research in tuberculosis drug discovery and development: A situation report with focus on Nigerian biodiversity
نویسندگان
چکیده
منابع مشابه
Current perspectives in drug discovery against tuberculosis from natural products.
Currently, one third of the world's population is latently infected with Mycobacterium tuberculosis (MTB), while 8.9-9.9 million new and relapse cases of tuberculosis (TB) are reported yearly. The renewed research interests in natural products in the hope of discovering new and novel antitubercular leads have been driven partly by the increased incidence of multidrug-resistant strains of MTB an...
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Discovery of a new drug is time consuming and laborious process. Natural products have long been a thriving source for the discovery of new drugs due to their chemical diversity and ability to act on various biological targets. The phytochemical exploration of indigeneous flora has contributed to some extent in this race for the discovery of new drugs. The traditional Indian systems of medicine...
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The medicinal use of natural products—compounds that are derived from natural sources such as plants, animals or micro-organisms—precedes recorded human history probably by thousands of years. Palaeoanthropological studies at the cave site of Shanidar, located in the Zagros Mountains of Kurdistan in Iraq, have suggested that more than 60,000 years ago, Neanderthals might have been aware of the ...
متن کاملNatural products in drug discovery.
Natural products have been the single most productive source of leads for the development of drugs. Over a 100 new products are in clinical development, particularly as anti-cancer agents and anti-infectives. Application of molecular biological techniques is increasing the availability of novel compounds that can be conveniently produced in bacteria or yeasts, and combinatorial chemistry approa...
متن کاملDrug Discovery and Development from Natural Products: The Way Forward
It is well established that natural products have been a source of leads for the development of many of the most effective drugs currently available for the treatment of a variety of human diseases. Biodiversity will continue to provide novel leads for drug development, but major obstacles limit efficient progress and result in decreased interest in the pharmaceutical sector. These include prob...
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ژورنال
عنوان ژورنال: African Journal of Biotechnology
سال: 2014
ISSN: 1684-5315
DOI: 10.5897/ajb2013.13491